Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences

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Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences.

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a widely used technique for assessing tissue physiology. Spoiled gradient echo (SPGR) pulse sequences are one of the most common methods for acquisition of DCE-MRI data, providing high temporal and spatial resolution with strong T(1)-weighting. Conversion of SPGR signal to concentration is briefly reviewed, and a new closed-form ...

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Rationale and Objectives. Accurate signal to tracer concentration maps are critical to quantitative MRI. The purpose of this study was to evaluate and optimize spoiled gradient echo (SPGR) MR sequences for the use of gadolinium (Gd-DTPA) as a kinetic tracer. Methods. Water-gadolinium phantoms were constructed for a physiologic range of gadolinium concentrations. Observed and calculated SPGR sig...

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ژورنال

عنوان ژورنال: Physics in Medicine and Biology

سال: 2008

ISSN: 0031-9155,1361-6560

DOI: 10.1088/0031-9155/53/9/010